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  • 03월 02일 17시 이후 : 초록수정 불가능, 일정확인 및 검색만 가능

제117회 대한화학회 학술발표회, 총회 및 기기전시회 NMR Spectroscopy based Metabolic Discrimination of Gallbladder Diseases

2016년 2월 18일 14시 36분 59초
ANAL2.O-11 이곳을 클릭하시면 발표코드에 대한 설명을 보실 수 있습니다.
금 10시 : 17분
분석화학 - 젊은 분석화학자의 구두 발표 II (Oral Presentation of Young Analytical Chemists II)
저자 및
고혜지, 최익장, 장결1, 공경현, 서형림, 정회일1,*, 이영복*
한양대학교 응용화학과, Korea
1한양대학교 화학과, Korea

Bile is one of the most abundant body fluid and metabolic components of bile are highly correlated with several gallbladder diseases. Gallbladder diseases (gallstones, gallbladder polys, cholecystitis and cancer) can usually be diagnosed by a physical exam, blood test, abdominal X-ray, and ultrasonography. Among them, ultrasonography is the most common diagnostic method since it reveals the existence of gallstones, thickened gallbladder walls, or other problems in gallbladder. However, because of its low spatial resolutions, it is hard pressed to precisely distinguish between gallstones and gallbladder polyps from the surrounding normal tissue by ultrasonography. Main purpose of this work is to identify several gallbladder diseases, especially gallstones and gallbladder polyps. We have performed detailed discrimination analysis (PCA analysis) and metabolic profiling of bile by using 1D and 2D 1H NMR spectroscopy. From these investigations, we found specific biomarkers (cholic acid and its derivatives) playing a significant role in discriminating gallstones, gallbladder polyps, and others. In conclusion, metabolic exploration based on 1H NMR spectroscopy provides a suitable guideline in differentiating gallbladder diseases.