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Bulletin of the Korean Chemical Society (BKCS)

ISSN 0253-2964(Print)
ISSN 1229-5949(Online)
Volume 17, Number 1
BKCSDE 17(1)
January 20, 1996 

 
Title
β-Lactam Derivatives as Inhibitors for Carboxypeptidase A. Enzyme Inhibitor Design, Part 17
Author
Dong H. Kim, Kwang-Rae Kim
Keywords
Abstract
2-(Azetidin-2-one-1-yl)-3-phenylpropionic acid and 2-(azetidin-2-thione-1-yl)-3-phenylpropionic acid were designed as potential active site directed inactivators for carboxypeptidase A, but shown to be they are competitive reversible inhibitors for the enzyme. The observation was somewhat surprising, but is not unexpected considering the recent report of Page who questioned the validity of the generally believed notion that β-lactam ring is highly unstable.
Page
34 - 38
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