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ISSN 0253-2964(Print)
ISSN 1229-5949(Online)
Volume 31, Number 8
BKCSDE 31(8)
August 20, 2010 |
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Title |
One Pot Synthesis of Substituted [1,2,4]-Triazolo [1’,2’:1,2]pyrimido [6,5-b]-quinoline and Its Antibacterial Activity
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Author |
Ratnadeep S Joshi, Priyanka G Mandhane, Asha V Chate, Wajid Khan, Charansingh H Gill* |
Keywords |
[1,2,4]-Triazolo [1’,2’:1,2]pyrimido[6,5-b]-quinoline, SiO2/K2CO3, Microwave irradiation, Antibacterial activity
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Abstract |
A convenient synthesis of substituted [1,2,4]-triazolo [1’,2’:1,2]pyrimido[6,5-b]-quinoline 4(a-i) from substituted 2-chloroquinoline-3-carbaldehyde 1(a-i) and 4H-1,2,4-triazol-3-amine 2 by using SiO2/K2CO3 under microwave irradiation. This method affords the [1,2,4]-Triazolo [1’,2’:1,2]pyrimido[6,5-b]-quinoline 4(a-i) under the influence of microwave irradiation in solvent-free conditions within short span (12 - 20 min), & gaves excellent yields (89 - 95%). All the synthesized compounds were further screened for their antibacterial activities. Some of our compounds showed excellent antibacterial activities against control drugs.
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2341 - 2344 |
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