 |
ISSN 0253-2964(Print)
ISSN 1229-5949(Online)
Volume 27, Number 11
BKCSDE 27(11)
November 20, 2006 |
|
| |
Title |
Preparation of a New Chiral Stationary Phase Based on (2S,3S)-O,O'-Bis-(10-undecenoyl)-N,N'-bis-(3,5-dinitrobenzoyl)-2,3-diamino-1,4-butandiol and Its Application for the Liquid Chromatographic Resolution of Enantiomers
|
Author |
Myung Ho Hyun*, Chang Jin Boo, Hee Jung Choi, Yun Kyoung Kim, Bu Sung Kang, Hyun Ju Ha, Min Ki Choi, Guanghui Tan
|
Keywords |
Chiral stationary phase, Enantiomer separation, Liquid chromatography
|
Abstract |
A new liquid chromatographic chiral stationary phase based on (2S,3S)-O,O'-bis-(10-undecenoyl)-N,N'-bis-(3,5-dinitrobenzoyl)-2,3-diamino-1,4-butandiol was prepared starting from (2R,3R)-1,4-bis(benzyloxy)-2,3-butanediol. The new chiral stationary phase was applied to the resolution of racemic anilide derivatives of Nacetyl-α-amino acids, 1,1'-bi-2-naphthol and 3,3'-diaryl-1,1'-bi-2-naphthols. The CSP was also applied to the resolution of some chiral drugs including a diuretic, bendroflumethiazide, and non-steroidal anti-inflammatory agents such naproxen and alminoprofen. In every case, the chiral recognition efficiency of the new CSP was quite excellent.
|
Page |
1769 - 1774 |
Full Text |
PDF
|
|
|
