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Bulletin of the Korean Chemical Society (BKCS)

ISSN 0253-2964(Print)
ISSN 1229-5949(Online)
Volume 26, Number 12
BKCSDE 26(12)
December 20, 2005

Title	Synthesis and COX Inhibitory Activities of Rutaecarpine Derivatives
Author	Eung Seok Lee, Seung Ill Kim, Seung Hoo Lee, Tae Cheon Jeong, Tae Chul Moon, Hyeun Wook Chang, Yurngdong Jahng
Keywords	Rutaecarpine, COX-2 inhibitor, Antiinflammatory activity, Indoloquinazoline alkaloid
Abstract	A series of substituted rutaecarpines were prepared by employing Fischer indole synthesis as key step and their inhibitory activities on COX-1 and 2 as well as selectivity on COX-2 were evaluated. The compounds with a methanesulfonyl and a bromo group at C10 showed promising inhibitory activity (IC₅₀ = 0.27, 0.35 μM, respectively) with selectivity.
Page	1975 - 0
Full Text	PDF

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