KCS Publications

HOME > Search > Browsing(BKCS) > Archives

Bulletin of the Korean Chemical Society (BKCS)

ISSN 0253-2964(Print)
ISSN 1229-5949(Online)
Volume 23, Number 11
BKCSDE 23(11)
November 20, 2002

Title	Synthesis of Tetracyclic Pyrido[2,3-b]azepine Derivatives as Analogues of Mirtazapine via N-Acyliminium Ion Cyclization
Author	Jae Yeol Lee, Sung Hun Bang, Sook Ja Lee, Yun Seon Song, Changbae Jin, Hokoon Park, Yong Sup Lee *
Keywords	Homooxacalix[4]arene, Conformation, Crystal structure
Abstract	Tetracyclic pyrido[2,3-b]azepine derivatives 4a-d and 4f as analogues of mirtazapine were synthesized via N-acyliminium ion cyclization by using aromatic rings such as benzene and thiophene ring as a π-nucleophile,and evaluated for the binding affinity for α₂-adrenoceptor. Among tested compounds, 2,3,9,13b-tetrahydro-1H-benzo[f]pyrrolo[2,1-a]pyrido[2,3-c]azepine (4a) was the most potent (Ki = 0.26 μM) but showed about 3-fold less binding affinity than mirtazapine (Ki = 0.08 μM) for a2-adrenoceptor.
Page	1623 - 1628
Full Text	PDF

How to access to the WOL for The Bulletin of the Korean Chemical Society ?

The Bulletin of the Korean Chemical Society will be co-published with Wiley-VCH from 2015 towards. The online version of the Journal will thus be available on Wiley Online Library, Wiley(-VCH)'s global online platform.

KCS members can get a free online access to the Bulletin of the Korean Chemical Society in WOL.

Free Access to WOL