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Bulletin of the Korean Chemical Society (BKCS)

ISSN 0253-2964(Print)
ISSN 1229-5949(Online)
Volume 23, Number 9
BKCSDE 23(9)
September 20, 2002 

Sonochemical Reformatsky Reaction Using Indium
Keukchan Bang, Kooyeon Lee, Yong Kwang Park, Phil Ho Lee
Indium, Reformatsky reaction, b-Hydroxyester, Sonochemical reaction
Sonochemical Reformatsky reaction of aldehydes or ketones with ethyl bromoacetate in the presence of indium afforded β-hydroxyesters in good to excellent yields under mild conditions. 2- or 3-Hydroxybenzaldehyde that contains an acidic hydrogen reacted with ethyl bromoacetate to provide the desired compounds with the same efficiency. In the case of ethyl 2-bromopropanoate and ethyl 2-bromo-2-methylpropanoate, the desired products were obtained in good yields. Reaction of aldehyde with indium reagent in the presence of ketone group proceeded chemoselectively.
1272 - 1276
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