KCS Publications

HOME > Search > Browsing(BKCS) > Archives

Bulletin of the Korean Chemical Society (BKCS)

ISSN 0253-2964(Print)
ISSN 1229-5949(Online)
Volume 21, Number 3
BKCSDE 21(3)
March 20, 2000

Title	Synthesis and Physicochemical Properties of Polynucleotide Analogues Containing Pyrimidine Bases
Author	Man Jung Han*, Ki Ho Kim, Kyung Soo Yoo, Young Dong Park, Ji Young Chang
Keywords
Abstract	Polynucleotide analogues containing pyrimidine (uracil and thymine) bases, poly[(1'- β-uracil-1-yl-2',5'-dideoxy-D-glycero-pent-4'-enofuranose)-alt-(maleic acid)] (12) and poly[(1'- b-thymin-1-yl-2',5'-dideoxy-D-glycero-pent-4'-enofuranose)-alt-(maleic acid)] (15), were synthesized by the alternating copolymerization of relevant nucleoside derivatives and maleic anhydride, and the subsequent hydrolysis. The polymers had quite similar structures to the natural polymers and were soluble in water. They showed high hypochromicities up to 49% and excimer fluorescence due to the base stacking, and polyelectrolyte behavior. Since the polymers had com-pact structures, depyrimidinations, the release of pyrimidine bases from the polymer backbone, occurred in aqueous solutions with higher rates compared with those of the natural polymers.
Page	321 - 327
Full Text	PDF

How to access to the WOL for The Bulletin of the Korean Chemical Society ?

The Bulletin of the Korean Chemical Society will be co-published with Wiley-VCH from 2015 towards. The online version of the Journal will thus be available on Wiley Online Library, Wiley(-VCH)'s global online platform.

KCS members can get a free online access to the Bulletin of the Korean Chemical Society in WOL.

Free Access to WOL