Current time in Korea 08:41 Oct 23 (Fri) Year 2020 KCS KCS Publications
KCS Publications
My Journal  Log In  Register
HOME > Search > Browsing(JKCS) > Archives

Journal of the Korean Chemical Society (JKCS)

ISSN 1017-2548(Print)
ISSN 2234-8530(Online)
Volume 37, Number 9
JKCSEZ 37(9)
June 20, 1993 

 
Title
Substitution Reactions of Cyanopyridines with Organometallics

유기금속화합물에 의한 Cyanopyridines의 치환반응에 관한 연구
Author
Jung Gyun Kim, Dong-Sik Yu, Sung-Hwan Moon, Jin Il Park, Won-Woo Park

김정균, 류동식, 문성환, 박진일, 박원우
Keywords
Abstract
3-Cyanopyridine을 organolithium 나 Grignard 시약과 반응시키면 6-위치에 첨가반응이 일어나 2-치환된 5-cyanopyridine류(6-치환된 3-cyanopyridine류)가 합성되었다. 반면, 2- 또는 4-cyanopyridine을 CH3Li이나 CH3MgI와 반응시키면, 각각 2-acetylpyridine과 4-acetylpyridine이 합성되었다.

3-Cyanopyridine, when treated with organolithium or Grignard reagents, gives addition to the 6-position and provides a series of 2-substituted 5-cyanopyridines (6-substituted 3-cyanopyridines). Alternatively, 2-and 4-cyanopyridine react with CH3Li or CH3MgI and provide 2-acetylpyridine and 4-acetylpyridine, respectively.

Page
826 - 831
Full Text
PDF