Abstract |
Fluorometholone (C22H29FO4), M.W. = 376.5, monoclinic, P21, a = 6.410(4), b = 13.431(3), c = 10.996(3)Å, β = 92.81(3)˚, Z = 2, F(000) = 404, T = 292K, λ(Mo-Kα) = 0.7107Å, μ = 0.57cm-1, Dc = 1.32 g/cm3, Dm = 1.31 g/cm3. 최종 R값은 1769개의 측정가능 회절반점들에 대하여 0.032 이었다. A 고리는 평면을 이루고 있으며, B 고리는 대칭성이 좋은 의자형이고, C 고리는 약간 찌그러진 의자형이다. D 고리는 13α-14β-half-chair와 13α-envelope의 중간형태이다. C(16)-C(17)-C(20)-O(20) torsion angle 값이 -7.9˚로 9-fluoro-6-methylprednisolone 분자 Ⅰ 와 Ⅱ의 -31.9˚와 -16.5˚보다 낮은 값을 보여준다. Fluorometholone (C22H29FO4), M.W. = 376.5, monoclinic, P21, a = 6.410(4), b = 13.431(3), c = 10.996(3)Å, β = 92.81(3)˚, Z = 2, F(000) = 404, T = 292K, λ(Mo-Kα) = 0.7107Å, μ = 0.57cm-1, Dc = 1.32 g/cm3, Dm = 1.31 g/cm3 and final R = 0.032 for 1769 observed reflections. All bond lengths and angles are within normal limits. Ring A is almost planar, B ring has a highly symmetrical chair conformation and C ring is in a distorted chair conformation. Ring D is in a intermediate conformation between 13α-14β-half-chair and 13α-envelope. Torsion angle C(16)-C(17)-C(20)-O(20) of -7.9˚ is a lower value than those of -31.9˚ and -16.5˚ for 9-fluoro-6-methylprednisolone Ⅰ and Ⅱ respectively. |
