ISSN 1017-2548(Print)
ISSN 2234-8530(Online)
Volume 35, Number 3
JKCSEZ 35(3)
June 20, 1991 

N1-alkyl-5-fluorouracil derivatives from 2-chloro-ethylacrylate(CEA) were synthesized. The reaction of 5-fluorouracil(5-FU) with 2-chloroethyl acrylate gave 1-hydroxyethyl-5-fluorouracil(HEFU) in 70% yield. The treatment of HEFU with acryloyl chloride afforded 1-acryloyloxyethyl-5-fluorouracil (AOEFU). Poly(1-acryloyloxyethyl-5-fluorouracil)[Poly(AOEFU)] was also synthesized from 5-fluorouracil and Poly(CEA). The hydrolysis rates of N1-alkyl-5-fluorouracil derivatives were observed by means of UV spectrophotometer at 265 nm in ethanol-water(1 : 1); k = the constant of hydrolysis rate, k = 1.38 × 10-4/sec for HEFU, k = 9.25 × 10-5/sec for AOEFU, k = 4.16 × 10-5/sec for Poly(AOEFU). The differential thermal analysis and thermogravimetry of 5-fluorouracil derivatives have been discussed.