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Journal of the Korean Chemical Society (JKCS)

ISSN 1017-2548(Print)
ISSN 2234-8530(Online)
Volume 26, Number 5
JKCSEZ 26(5)
October 20, 1982 
 
Title
 Peptide-Water Interaction. Effects of Pressure and Temperature on the Solubility of 1-Phenyl-2-acetamido-3-butanone

펩티드-물 상호작용. 1-페닐-2-아세트아미도 3-부탄온의 용해도에 대한 압력과 온도의 영향
Author
 In-Ja Lee, Sang-Wook Kang, Doo-Soon Shin, Keon Kim

이인자, 강상욱, 신두순, 김건
Keywords
Abstract
 수용액 속에서 1-페닐-2-아세트아미도-3-부탄온의 용해도를 20, 30, 40℃에서 또 1kg/cm2에서 4500 kg/cm2까지의 압력에서 측정하였다. 압력이 커질수록 용해도는 감소한다. 이러한 용해도 변화는 디케토피페라진과 아주 비슷하다. 디케토피페라진이 펩타이드 결합의 모델 화합물이라는 점과 1-페닐-2-아세토아미도-3-부탄온이 한개의 펩타이드 결합과 상당히 큰 소수성 작용기를 가졌다는 점을 고려할 때 이와 같은 용해도 변화는 예상 밖이다. 부피 변화와 열용량 변화에 대한 값은 이상하다고 할 정도는 아니었다.

The solubilities of 1-phenyl-2-acetamido-3-butanone were measured in H2O at 20, 30 and 40℃ at pressure from 1 to 4500 kg/cm2. Pressure going up to 4500 kg/cm2, the solubility in H2O decreases consistantly as that of diketopiperazine does. As diketopiperazine is a model compound of peptide bond and 1-phenyl-2-acetamido-3-butanone has only one peptide bond and a pretty large hydrophobic group, the solubility behavior is quite surprising. Volume change and heat capacity change data are reasonable.
Page
 296 - 303
Full Text
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