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Journal of the Korean Chemical Society (JKCS)

ISSN 1017-2548(Print)
ISSN 2234-8530(Online)
Volume 21, Number 4
JKCSEZ 21(4)
August 20, 1977 
 
Title
 The Study on Conformation and Biological Activity for the Drug Design. Phenethylamine Derivatives as the Sympathomimetics

새로운 의약품의 개발을 위한 의약품의 분자구조와 약리효과에 관한 연구. 교감신경모방약으로 작용하는 Phenethylamine 유도체들에 관하여
Author
 Ui Rak Kim

김의락
Keywords
Abstract
 교감신경 흥분성 amine류의 분자구조와 약리효과 간의 관계를 설명하기 위하여 phenethylamine에서 benzene 고리와 ethylamine의 α, β 위치와 amine의 질소에 hydroxy기와 methyl기 등을 도입한 23종의 약품에 대한 분자 특성을 EHT법으로 계산하여 검토하였다.

We applied the EHT method to 23 kinds of adrenergic agents, sympathomimetics, which were derived from phenethylamine by introducing hydroxy and methyl group to benzene ring, α-or β-position and nitrogen of ethylamine. We have stated and discussed theoretically the relationship between their structural characteristics and biological activities by compairing with the calculated values.
Page
 235 - 245
Full Text
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