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Journal of the Korean Chemical Society (JKCS)

ISSN 1017-2548(Print)
ISSN 2234-8530(Online)
Volume 13, Number 2
JKCSEZ 13(2)
April 20, 1969 

Reaction of Nitrous Acid on 5-Aminopyrimidine (Ⅳ) The Synthesis of 5-Cyano-and 5-Carboxypyrimidines

5-Aminopyrimidine에 대한 아질산의 반응 (Ⅳ) 5-Cyano 및 5-CarboxyPyrimidine 유도체의 합성
Sae Hee Chang, Jae Soon Kim, Tae Soung Huh

장세희, 김재순, 허태성
5-Cyanopyrimidine 유도체를 5-Aminopyrimidine 유도체로부터 Sandmeyer반응에 의하여 합성하고 이 화합물들을 가수분해하여 Pyrimidine-5-carbolylic acid 을 합성하였다. 이 방법에 의하면 불순물 제거의 어려움 없이 5-Cyanopyrimidine유도체와 Pyrimidine-5-carboxylic acid유도체를 62%와 65%의 수율로 합성할 수 있었다.

5-Cyanopyrimidine derivatives were synthesized starting from 5-aminopyrimidine derivatives through the extended Sandmeyer reaction, and then these compounds were hydrolyzed to obtain pyrimidine-5-carboxylic acids. According to this procedure, 5-cyanopyrimidine derivatives and pyrimidine-5-carboxylic acid derivatives have been prepared in 62% and 65% yields, respectively, without any difficulties in removing impurities.

177 - 180
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