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Journal of the Korean Chemical Society (JKCS)

ISSN 1017-2548(Print)
ISSN 2234-8530(Online)
Volume 66, Number 1
JKCSEZ 66(1)
February 20, 2022

Title	Intramolecular Oxa-Mannich Reaction of 1,3-Dihydro-2-benzofuran-1-ol for Efficient Synthesis of 1-Aminophthalan Derivatives
Author	Heebum Kim, Sung Gon Kim*
Keywords	1,3-Dihydroisobenzofuran, Phthalan, p-Toluenesulfonylamine, Mannich reaction
Abstract	An efficient method for the synthesis of 1-aminophthalans has been developed. The intramolecular oxa-Mannich reaction of 1,3-dihydro-2-benzofuran-1-ols with p-toluenesulfonylamine in the presence of Cs2CO3 as a base, without using any catalyst, provided the desired 1-aminophthalans in moderate to good yields.
Page	9 - 14
Full Text	PDF

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