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Journal of the Korean Chemical Society (JKCS)

ISSN 1017-2548(Print)
ISSN 2234-8530(Online)
Volume 61, Number 6
JKCSEZ 61(6)
December 20, 2017 

 
Title
The Effect of Wettability and Protein Adsorption of Contact Lens by Alginic Acid

알긴산에 의한 콘택트렌즈의 습윤성과 단백질 흡착 효과
Author
Na Young Ko, Kyung Mun Lee, Hyun Mee Lee*

고나영, 이경문, 이현미*
Keywords
알긴산, 습윤성, 산소투과성, 단백질 흡착, IPN , Alginic acid, Wettability, Oxygen permeability, Protein adsorption, IPN
Abstract
하이드로겔 콘택트렌즈의 습윤성 향상과 단백질 흡착량 감소을 위해 천연다당류인 알긴산을 첨가하였다. 하이드로겔 콘택트렌즈는 2-Methacryloyloxyethyl phosphorylcholine(MPC)와 NVP(N-Vinyl-2-pyrrolidone)와 같은 다양한 단량체를 이용하여 제작하였다. 알긴산 첨가방법은 초기 혼합 방법과 IPN (Interpenetrating Polymer Network) 방법을 사용하였다. 콘택트렌즈의 특 성 평가를 위해 접촉각, 산소 투과도 및 단백질 흡착 량 등을 측정하였다. 산소 투과도와 습윤성 등 물리적 특성이 알긴산으로 IPN 으로 처리 한 시료가 IPN으로 처리하지 않은 시료보다 높았다. 단백질 흡착은 알긴산의 첨가에 의해 감소되었고 IPN처리를 통 해 더욱 감소되었다. 특히, MPC 및 NVP를 함유한 콘택트렌즈는 단백질 흡착을 상당히 감소시켰다. 따라서 알긴산이 콘택트렌 즈의 기능 향상에 미치는 영향을 확인 하였다.

The addition of alginic acid, a natural polysaccharide, to improve the wettability and the reduction of protein adsorption of hydrogel contact lenses. Hydrogel contact lenses were manufactured with various monomers such as 2-methacryloyloxyethyl phosphorylcholine (MPC) and NVP (N-Vinyl-2-pyrrolidone). Alginic acid was added by by the initial mixing method and the interpenetrating polymer networks(IPN) method. Properties of contact lens such as contact angle, oxygen permeability, and protein adsorption amount were evaluated. The oxygen permeability and wettability of the IPN-treated alginate samples were higher than those of the samples that were not treated with IPN. The physical properties were improved as the concentration of IPN-treated alginic acid increased. Protein adsorption decreased by the addition of alginic acid and further decreased with IPN. In particular, contact lenses containing MPC and NVP significantly decreased protein adsorption. Therefore, the effect of alginate on the functional improvement of contact lens was confirmed.

Page
352 - 358
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