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Journal of the Korean Chemical Society (JKCS)

ISSN 1017-2548(Print)
ISSN 2234-8530(Online)
Volume 58, Number 2
JKCSEZ 58(2)
April 20, 2014 

Cyclic Voltammetric Investigation of Interactions between Bisnitroaromatic Compounds and ds.DNA
Naveed Kausar Janjua*, Zareen Akhter, Fariya Jabeen, Bushra Iftikhar
Bisnitrocompounds, ds.DNA binding, Cyclic voltammetry, Threading intercalation
Herein, the cyclic voltammetric (CV) investigations of structurally similar bisnitrocompounds (N3, N4, N5, N6, having different -CH2- spacer length) is presented. CV study offered interesting interactional possibilities of bisnitrocompounds with chicken blood ds.DNA at physiological pH 4.7 and human body temperature, 310 K. The results indicated strong interaction by these symmetric molecules with ds.DNA and strength of binding is found to depend on length of CH2 spacer group in their molecular structure. Thermodynamics derived from electrochemical binding parameters also favored the irreversible interactions. Moreover, threading intercalation mode of binding is suggested based on thermodynamic and kinetic binding parameters extracted from CV studies.
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