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Journal of the Korean Chemical Society (JKCS)

ISSN 1017-2548(Print)
ISSN 2234-8530(Online)
Volume 55, Number 5
JKCSEZ 55(5)
October 20, 2011 

 
Title
Synthesis of Novel Series of Various Substituted1-(5-(2-p-tolyloxyquinolin-3-yl)-2-(pyridin-4-yl)-1,3,4-oxadiazol-3(2H)-yl)ethanone and its Antibacterial Activity
Author
Ratnadeep S Joshi, Priyanka G Mandhane, Asha V Chate, Charansingh H Gill*
Keywords
1,3,4 oxadiazole, Quinoline, Isoniazide, Cyclisation, Antibacterial activity
Abstract
A new series of 1-(5-(2-tolyloxyquinoline-3-yl)-2-(pyridine-4-yl)-1,3,4-oxidiazol-3(2H)-yl)ethanones were synthesized from cyclisation of N’-((2-(p-tolyloxy)quinoline-3-yl)methylene) isonitonohydrazide in acetic unhydride at reflux condition for 3-4 hr. The structures of the new compounds were confirmed by elemental analyses as well as IR, 1H NMR and mass spectral data. All the synthesized compounds were screened for their antibacterial activities against various bacterial strains. Several of these compounds showed potential antibacterial activity.
Page
760 - 764
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