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Journal of the Korean Chemical Society (JKCS)

ISSN 1017-2548(Print)
ISSN 2234-8530(Online)
Volume 55, Number 4
JKCSEZ 55(4)
August 20, 2011 

 
Title
Synthesis and Antibacterial Evaluation of Some Novel 1,3,4-oxadiazol Derivatives Incorporated with Quinoline Moiety

Quinoline moiety를 가지고 있는 1,3,4-oxadiazol 유도체의 합성 및 항균활성
Author
Priyanka G Mandhane, Ratnadeep S Joshi, Wajid Khan, Charansingh H Gill*

Priyanka G Mandhane, Ratnadeep S Joshi, Wajid Khan, Charansingh H Gill*
Keywords
Gallic acid, 1,3,4-Oxadiazole, Quinoline-3-carbaldehyde, 항균활성 , Gallic acid, 1,3,4-Oxadiazole, Quinoline-3-carbaldehyde, Antibacterial activity
Abstract
5-(3,4,5-Triethoxyphenyl)-1,3,4-oxadiazole-2-thiol 6을 3-(bromomethyl)-2-chloroquinoline or 2-(p-tolyloxy)-3-(bromomethyl) quinoline 4a-j 화합물과 반응시켜서 3-((5-(3,4,5-triethoxyphenyl)-1,3,4-oxadiazol-2-ylthio)methyl)-2-chloroquinoline 또는 3-((5- (3,4,5-triethoxyphenyl)-1,3,4-oxadiazol-2-ylthio)methyl)-2-(p-tolyloxy)quinoline 7a-j를 합성하였다. 합성한 화합물들에 대한 항 균활성을 측정하였으며, 화합물 7d, 7i 및 7j 은 우수한 활성을 나타내었다.

5-(3,4,5-Triethoxyphenyl)-1,3,4-oxadiazole-2-thiol 6 on treatment with substituted 3-(bromomethyl)-2-chloroquinoline or 2-(p-tolyloxy)-3-(bromomethyl)quinoline 4a-j afforded the corresponding 3-((5-(3,4,5-triethoxyphenyl)-1,3,4-oxadiazol-2- ylthio)methyl)-2-chloroquinoline or 3-((5-(3,4,5-triethoxyphenyl)-1,3,4-oxadiazol-2-ylthio)methyl)-2-(p-tolyloxy)quinoline 7a-j, in the presence of K2CO3 and DMF under stirring at ambient temperature. All the synthesized compounds were further screened for their antibacterial activities. Some of our compounds showed excellent antibacterial activities against test organisms and reference standard.

Page
656 - 661
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