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Journal of the Korean Chemical Society (JKCS)

ISSN 1017-2548(Print)
ISSN 2234-8530(Online)
Volume 55, Number 2
JKCSEZ 55(2)
April 20, 2011 

 
Title
Synthesis of Pyrimidines and Heteroannulated Pyrimidine Ring Systems

Pyrimidines과 pyrimidine의 헤테로고리의 합성
Author
F K Mohammed*, M G Badrey

F K Mohammed*, M G Badrey
Keywords
피리미딘, 트리아졸로피리미딘, 트리아지노피리미딘, 벤조피란 유도체 , Pyrimidine, Triazolopyrimidine, Triazinopyrimidine, Benzopyran derivatives
Abstract
Imine 화합물 1을 hydrazine hydrate와 같은 nitrogenous 시약과 반응시켜서 치환된 pyrimidines 화합물을 합성하였 다. 얻어진 화합물 2를 다양한 반응조건, 즉 propionic acid, formic acid, ethyl chloroformate, acdetic anhydride, carbon disulphide, cyanogene bromide, triflauroacetic acid 및 ethyl chloroacetate와 반응시켜서 대응하는 화합물을 좋은 수율로 얻었 으며, 반응은 Dimroth-type 자리옮김 반응을 통하여 진행되었다.

We have involved the imine compound 1 in condensations with various nitrogenous reagents including hydrazine hydrate to construct differently substituted pyrimidines. One of the pyrimidines so obtained was further subjected to interactions with different reagents such as propionic acid, formic acid, ethyl chloroformate, acdetic anhydride, carbon disulphide, cyanogene bromide, triflauroacetic acid and ethyl chloroacetate which resulted in the formation of annulated heterocyclic systems as pairs of isomers in most cases as a result of Dimroth-type rearrangement.

Page
218 - 229
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