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Journal of the Korean Chemical Society (JKCS)

ISSN 1017-2548(Print)
ISSN 2234-8530(Online)
Volume 54, Number 1
JKCSEZ 54(1)
February 20, 2010 

 
Title
Synthesis and Antimicrobial Screening of Some Fluorinated Azoles Containing (2-(6-Methyl-2-P-tolyl-lH-imidazo[1,2-a]pyridin-3-yl) Nucleus

2-(6-Methyl-2-P-tolyl-lH-imidazo[1,2-a]pyridin-3-yl)핵종을 가지고 있는 불소화된 아조화합물의 합성과 항균활성의 스크리닝
Author
Sharad Shelke*, Nilesh Salunkhe, Sandeep Sangale, Swapnil Bhalerao, Nilesh Naik, Ganesh Mhaske, Ranjana Jadhav, Bhausaheb Karale

Sharad Shelke*, Nilesh Salunkhe, Sandeep Sangale, Swapnil Bhalerao, Nilesh Naik, Ganesh Mhaske, Ranjana Jadhav, Bhausaheb Karale
Keywords
불소화된 아졸, 트리아졸, 티아디아졸, 옥사티아졸, 초음파, 항균활성 , Fluorinated azoles, Triazoles, Thiadiazoles, Oxadiazoles, Ultrasound, Antibacterial activity
Abstract
일련의 불소화된 티아디아졸 3, 트리아졸 4, 그리고 옥사디아졸 5이 (2-(6-Methyl-2-P-tolyl-lH-imidazo[1,2-a]pyridin-3-yl)핵종을 가지고 있는 티오세미카르바지드로 부터 합성되어진다. 초음파조사 방법 뿐만 아니라 일반적인 방법에 의해 반응이 진행되었다. 모든 생성물들은 IR, 1H NMR, MS로 구조가 결정되었고, 이들 화합물의 항균활성을 스크닝하였다.

The synthesis of a series of fluorinated thiadiazoles 3, triazoles 4 and oxadiazoles 5 are synthesized from thiosemicarbazides 2 containing (2-(6-methyl-2-p-tolyl-lH-imidazo[1,2-a]pyridin-3-yl nucleus. These reactions were carried out by conventional method as well as ultra sound irradiation method. All products have been characterized by IR, 1H NMR, MS study and screened for their antimicrobial activity.

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59 - 64
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