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Journal of the Korean Chemical Society (JKCS)

ISSN 1017-2548(Print)
ISSN 2234-8530(Online)
Volume 54, Number 1
JKCSEZ 54(1)
February 20, 2010 

 
Title
Design, Synthesis and Spectral Characterization of Novel 2-morpholino-N-(4,6-diarylpyrimidin-2-yl)acetamides

새로운 2-morpholino-N-(4,6-diarylpyrimidin-2-yl)acetamides의 합성과 분광학적 특성의 연구
Author
Vijayakumar Kanagarajan, Jayaraman Thanusu, Mannathusamy Gopalakrishnan*

Vijayakumar Kanagarajan, Jayaraman Thanusu, Mannathusamy Gopalakrishnan*
Keywords
2-Morpholino-N-(4,6-diarylpyrimidin-2-yl)acetamides, 2-Chloro-N-(4,6-diarylpyrimidin-2-yl)acetamides, 모르포린, 클로로아세틸화반응 , 2-Morpholino-N-(4,6-diarylpyrimidin-2-yl)acetamides, 4,6-Diarylpyrimidin-2-amines, Chloroacetylation, Morpholine, Synthesis
Abstract
무수탄산칼륨 존재 하에서 2-chloro-N-(4,6-diarylpyrimidin-2-yl)acetamides 25-33를 모르포린과 축합 반응시켜서 2-morpholino-N-(4,6-diarylpyrimidin-2yl)acetamides 34-42 화합물들을 합성하였다. 합성된 화합물들의 녹는점, 원소분석, MS, FT-IR, 1H- & 13C-NMR로 화학적인 구조를 규명되었다.

A new series of novel 2-morpholino-N-(4,6-diarylpyrimidin-2-yl)acetamides 34-42 is synthesized by the condensation of 2-chloro-N-(4,6-diarylpyrimidin-2-yl)acetamides 25-33 with morpholine in the presence of anhydrous potassium carbonate. The synthesized compounds have been characterized by melting point, elemental analysis, MS, FT-IR, one-dimensional NMR (1H & 13C) spectroscopic data.

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