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Journal of the Korean Chemical Society (JKCS)

ISSN 1017-2548(Print)
ISSN 2234-8530(Online)
Volume 52, Number 6
JKCSEZ 52(6)
December 20, 2008 
 
Title
 Development and Validation of Simultaneous UV Spectrophotometric Method for the Determination of Levofloxacin and Ambroxol in Tablets

알약에서의 Levofloxacin와 Ambroxol의 검출을 위한 동시 UV 분광법의 개발 및 검정
Author
 Tabassum Patil, Yogesh Pore*

Tabassum Patil, Yogesh Pore*
Keywords
 Levofloxacin Hemihydrate, Ambroxol Hydrochloride, UV 분광법, Q 분석, 투여량 형태 , Levofloxacin Hemihydrate, Ambroxol Hydrochloride, UV Spectrophometry, Q analysis, Dosage Form
Abstract
 알약형태에 포함되어 있는 levofloxacin (LFX)과 ambroxol (ABX) 을 동시분석하기 위하여 정확하고, 정 밀한 UV 분광법을 개발하였다. 이 방 법은 용매로서 증류수를 사용하여 219 (등흡광점)와 287 nm에서 Q-흡수 방정식 의 형성을 포함하고 있다. Levofloxacin과 ambroxol에 대한 직선성은 각각 2-20 μg/ml와5-50 μg/ml 범위 이다. 회 수율은 알약에서 levofloxacin와 ambroxol 각각에 대하여 100-101%와 99-102% 였다. 이 결과는 알약에서 알약에서 levofloxacin와 ambroxol를 정확하고 정밀하게 동시에 평가할 수 있음을 알 수 있다.

An accurate, specific and precise UV spectrophotometric method was developed for the simultaneous determination of levofloxacin (LFX) and ambroxol (ABX) in pharmaceutical dosage forms. The method involves formation of Q-absorbance equation at 219 (isoabsorptive point) and at 287 nm, using distilled water as a solvent. The linearity for both levofloxacin and ambroxol was in the range of 2-20 μg/ml and 5-50 μg/ml respectively. The % recovery was found to be 100-101% and 99-102% for levofloxacin and ambroxol respectively indicating proposed method is accurate and precise for simultaneous estimation of levofloxacin and ambroxol in tablets.

Page
 622 - 629
Full Text
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