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Journal of the Korean Chemical Society (JKCS)

ISSN 1017-2548(Print)
ISSN 2234-8530(Online)
Volume 52, Number 3
JKCSEZ 52(3)
June 20, 2008 

 
Title
Synthesis, Characterization and Bioevaluation of New Tetrahydroquinazolines

새로운 Tetrahydroquinazoline의 합성, 구조 결정 및 생물학적 평가
Author
Y. L. N. Murthy*, P. V. N. Acharyulu, P. K. Dubey, T. Tirunala Sundari

Y. L. N. Murthy*, P. V. N. Acharyulu, P. K. Dubey, T. Tirunala Sundari
Keywords
Tetrahydroquinazolines, cyclohexanones, 무독성 항균병원체들 , Tetrahydroquinazolines, Cyclohexanones, Non-toxic Antibacterial Agents
Abstract
새로운 다섯개의 tetrahydroquinazolines 의 합성과 구조 결정 및 생물학적 평가는 보고 되었다. 최초에 준비된 cyclohexanones는 목표분자를 얻기 위한 synthon으로 사용되어졌다. 이들은 치환된 벤즈알데히드와 결합되어졌고, 얻어진 chalcone은 구아니딘 염산염으로 처리했다. 모든 분자들은 인간세포에 무독하며 상당한 항균성을 보여줬다.

The synthesis, characterization and bioevaluation of five new tetrahydroquinazolines was reported. Initially cyclohexanones were prepared and they were used as synthons to get the target molecules. These were condensed with substituted benzaldehydes and the resulting chalcones were treated with guanidine hydrochloride . All the molecules were non-toxic to human cells and showed significant antibacterial activity.

Page
257 - 265
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