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Journal of the Korean Chemical Society (JKCS)

ISSN 1017-2548(Print)
ISSN 2234-8530(Online)
Volume 48, Number 2
JKCSEZ 48(2)
April 20, 2004

Title	Ecofriendly Synthesis of Antifungal Azoles Ecofriendly Synthesis of Antifungal Azoles
Author	Kidwai M., Mohan R. Kidwai M., Mohan R.
Keywords	고체지지체, 마이크로파 쬐임, 항진균성 활성도, 트라이아졸, 피라졸론, 옥사다이아졸 , Solid Support, Microwave Irradiation (MWI), Antifungal Activity, Triazoles, Pyrazolones, Oxadiazoles
Abstract	1,2,4-트라이아졸, 피라졸론, 그리고 1,3,4-옥사다이아졸을 마이크로파 쬐임(MWI) 하에서 여러 가지 고체지지체를 이용하여 치환기가 있는 하이드라자이드로부터 합성하였다. 그 얻어진 실험 결과들은 고체지지체의 다양성을 보여준다. 합성한 모든 유도체들을 A. niger와 A. flavus 균주에서 항진균성활성도를 조사한 하였으며 좋은 활성을 보여 주었다. 1,2,4-Triazoles, pyrazolones and 1,3,4-oxadiazoles have been synthesized from substituted hydrazide using various solid supports under microwave irradiation (MWI). The results obtained highlight the versatility of the solid supports. All synthesized compounds were screened for their antifungal activity against A. niger and A. flavus and were found to possess good activity.
Page	177 - 0
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