Current time in Korea 08:21 Apr 27 (Sat) Year 2024 KCS KCS Publications
KCS Publications
My Journal  Log In  Register
HOME > Search > Browsing(JKCS) > Archives

Journal of the Korean Chemical Society (JKCS)

ISSN 1017-2548(Print)
ISSN 2234-8530(Online)
Volume 48, Number 2
JKCSEZ 48(2)
April 20, 2004 

 
Title
Analysis of 2-Mercapro-1-Methylimidazole in Controlling Drug of Thyroid by Differential Pulse Polarography

펄스차이 폴라로그래피를 이용한 갑상선기능조절 약제 중의 2-mercapto-1-methyl-imidazole 분석
Author
Il Kwang Kim*, Hyun Ja Chun, Sung Soo Han

김일광*, 천현자, 한성수
Keywords
항갑상선 약제, 2-mercapto-1-methyl-imidazole, 펄스차이폴라로그래피 , Antithyroid, 2-Mercapto-1-Methyl-imidazole, Differential Pulse Polarography
Abstract
5.0×10-2 M LiClO4 지지전해질에서 2-mercapto-1-methyl-imidazole(MMI)의 분석을 펄스차이폴라로그래피로 조사하였다. MMI의 분석에서 적절한 조건은 다음과 같다; 초기전위: -0.9 volts, 펄스세기: 0.08 mV, 주사속도: 2 mV/sec. 표준검량곡선은 1.0×10-7~8.0×10-5 M 범위에서 좋은 직선성을 보였으며, 검출한계는 (2.2±0.1) X 0.1-9 M이었다. 이 방법으로 첨가제의 방해없이 항갑상선 약제중의 MMI를 정량하는데 응용하였다.

The determination of 2-mercapto-1-methyl-imidazole (MMI) in 5.0x10-2 M lithium perchlorate suporting electrolyte has been investigated by the differential pulse polarography. The optimum condition of MMI analysis was as follows; -0.9 volts initial potential, 0.08 mV pulse height, 2 mV/sec scan rate, and medium mercury drop size. Standard calibration curve showed a good linearlity in the range of 1.0X10-7 M to 8.0X10-5 M and the detection limit has been (2.2±0.1) X 0.1-9 M. This method was applicated for the determination of MMI in antithyroid drug without interference of additives.

Page
137 - 0
Full Text
PDF