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Bulletin of the Korean Chemical Society (BKCS)

ISSN 0253-2964(Print)
ISSN 1229-5949(Online)
Volume 19, Number 12
BKCSDE 19(12)
December 20, 1998 

Simultaneous Determination of Urinary Metabolites of Workers Exposed to Benzene, Toluene and Xylene Mixture with HPLC using β-Cyclodextrine
Deog Hwan Moon, Yong Hee Lee, Chan-Seok Moon, Joung Ho Kim, Myung hee Park, Chae Un Lee, Nak Whan Paik, Yoon-Bo Shim
The high-performance liquid chromatographic determination of eight metabolites was evaluated with a β-cyclodextrine (β-CD) added C18 column. The urinary metabolites were hippuric acid (HA), phenol, o-, m-, p-methylhippuric acid (MHA) and o-, m-, p-cresol in untreated urine samples of factory workers exposed to benzene, toluene and xylene mixture. Eluting sequence of eight metabolites was shown to be the order of HA, o-MHA, phenol, p-MHA, M-MHA, p-cresol, m-cresol, and o-cresol. The optimum ratio of the mobile phase was selected 20/80/0.3/1.4% to ethanol/water/acetic acid/β-CD, in which was shown 2
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