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Bulletin of the Korean Chemical Society (BKCS)

ISSN 0253-2964(Print)
ISSN 1229-5949(Online)
Volume 11, Number 6
BKCSDE 11(6)
June 20, 1990 

 
Title
Proteolysis of Glucagon Bound to Dimyristoylphosphatidylcholine Vesicle
Author
Gwansu Yi, Hyoungman Kim*
Keywords
Abstract
Glucagon was found to interact with DMPC vesicles electrostatically and hydrophobically. It appears that glucagon bound irreversibly to the vesicles through hydrophobic interaction was partially protected from the proteolysis by trypsin. Out of three possible sites, only the peptide bond preceded by Arg-18 was cleaved by a prolonged trypsin treatment. α-chymotrysin did not affect the vesicle-bound glucagon. Based on these observations, possible structure of irreversibly bound glucagon on the vesicle surface is discussed.
Page
534 - 538
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