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Bulletin of the Korean Chemical Society (BKCS)

ISSN 0253-2964(Print)
ISSN 1229-5949(Online)
Volume 10, Number 1
BKCSDE 10(1)
January 20, 1989 

 
Title
Application of BMPI / HOBT Reagent in Solid-Phase Peptide Synthesis
Author
Nam Joo Hong*, Soo Kwan Choi, Soon Uoong Koock
Keywords
Abstract
The suitability of BMPI (2-bromo-N-methyl pyridinium iodide) for solid-phase peptide synthesis was investigated. The coupling rate of BMPI/HOBT procedure. BMPI/HOBT was superior to DCC/HOBT couplings using the solid-phase peptide bond formation proceeded to a greater degree of completion than DCC/HOBT method did. Double couplings with 2 equiv. of Bocamino acids and 1.5 equiv. of BMPI and NEt3 and 2 equiv. of HOBT in DMF/MC (1:1 v/v) gave the best result for the preparation of a model compound. Stepwise solid phase peptide synthesis using BMPI/HOBT procedure was successfully utilized for the preparation of (D-Ala)2-dynorphine A. BMPI/HOBT procedure for the synthesis of (D-Ala)2-dynorphine gave better yield (20%) than DCC/HOBT procedure did.
Page
19 - 22
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