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Bulletin of the Korean Chemical Society (BKCS)

ISSN 0253-2964(Print)
ISSN 1229-5949(Online)
Volume 9, Number 4
BKCSDE 9(4)
April 20, 1988 

 
Title
Synthesis of new Hydantoin-3-Acetic acid Derivatives
Author
Chang-Hyun Oh, Yong-Koo Kang, Sang-Woo Park, Jung-Hyuck Cho*, Soon-Kyung Kwon
Keywords
Abstract
Through the Bucherer-Berg method, new 5-alkylthiomethyl or 5-alkylsulfonylmethylhydantoins were prepared. The reaction of ethyl chloroacetate with these compounds gave 3-acetate and the subsequent hydrolysis with dilute sodium hydroxide resulted in 3-hydantoinacetic acid derivatives. These products are expected to exhibit anti-inflammatory and analgestic activities.
Page
231 - 235
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