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Bulletin of the Korean Chemical Society (BKCS)

ISSN 0253-2964(Print)
ISSN 1229-5949(Online)
Volume 8, Number 5
BKCSDE 8(5)
May 20, 1987 

 
Title
Synthetic β-Lactam Antibiotics Ⅱ. Synthesis and Antibacterial Activity of 7β-[2-(2-Aminothiazol-4-yl)-2-(methoxyimino)acetamido]-3-[1-(halosubstitutedphenyl)-1H-tetrazol-5-yl]thiomethyl-cephalosporins
Author
Dongsoo Koh, Joong-Hyup Kim, Sang-Woo Park, Youseung Kim*
Keywords
Abstract
Syntheses of cefotaxime analogs with halosubstituted phenyltetrazolthiomethyl at the C3-position are described. Their in vitro potency was established. The compounds exhibited a broad antibacterial spectrum. Some of these compounds showed activity against Gram-positive bacteria superior to the parent cefotaxime. Against Gram-negative bacteria, these compounds are less effective than cefotaxime.
Page
418 - 421
Full Text
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