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Bulletin of the Korean Chemical Society (BKCS)

ISSN 0253-2964(Print)
ISSN 1229-5949(Online)
Volume 35, Number 12
BKCSDE 35(12)
December 20, 2014

Title	Synthesis of Dithiolopyrrolone Derivatives and Their Leukocyte-Increasing Activities
Author	Chungang Li, Yiping Sun, Guoping Wang, Xiangduan Tan*
Keywords	Dithiolopyrrolone derivatives, Leukocyte-increasing activity, Leukopenia, Antileukopenia, rhGCSF
Abstract	In search of new antileukopenia agents, twenty dithiolopyrrolone derivatives were synthesized and evaluated for their leukocyte-increasing activities in normal mice. Among the synthesized compounds 4-23, compounds 5 and 6 showed significant leukocyte-increasing activity ( p < 0.01), and compounds 4, 9 and 16 had a moderate effect ( p < 0.05). Compound 5 also displayed stronger leukocyte-increasing activity than that of the positive recombinant human granulocyte colony stimulating factor (rhG-CSF). Above all, compound 5 would be a potential antileukopenia agent which deserved further research.
Page	3489 - 3494
Full Text	PDF

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