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Bulletin of the Korean Chemical Society (BKCS)

ISSN 0253-2964(Print)
ISSN 1229-5949(Online)
Volume 35, Number 8
BKCSDE 35(8)
August 20, 2014 

NF-κB Activation and PPAR Transactivational Effects of a New Aliphatic Acid Amide from Pericarps of Zanthoxylum piperitum
Seo Young Yang, Bui Huu Tai, Seok Bean Song, Wei Li, Xi Tao Yan, Ya Nan Sun, Nguyen Phuong Thao,, Young Ho Kim*
ZP-amide F, Zanthoxylum piperitum, Anti-inflammation, NF-κB, PPAR
A new aliphatic acid amide, ZP-amide F (1), and eight known compounds, including bungeanumamide A (2), tumuramide C (3), ZP-amide A (4), ZP-amide B (5), ZP-amide D (6), hyperin (7), quercitrin (8), and (−)- sesamin (9), were isolated from pericarps of Zanthoxylum piperitum. The effects of these compounds on TNFα-induced NF-κB activation and transactivational activity of PPARs, including PPARα, PPARβ(δ) and PPARγ subtypes, were evaluated. Compounds 7 and 9 exhibited potent inhibitory effects on TNFα-induced NF-κB activation with IC50 values of 5.50 and 8.10 μM, respectively. Aliphatic acid amide compounds 3, 4 and 6 displayed enhanced effects on PPAR transactivational activity with EC50 values of 47.12, 19.13 and 12.02 μM, respectively. Among them, compound 4 demonstrated an increase in PPARα transactivational activity, compound 3 showed a moderate increase on all PPAR subtypes, whereas compound 6 displayed weak PPAR transactivational activity.
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