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ISSN 0253-2964(Print)
ISSN 1229-5949(Online)
Volume 35, Number 8
BKCSDE 35(8)
August 20, 2014 |
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Title |
NF-κB Activation and PPAR Transactivational Effects of a New Aliphatic Acid Amide from Pericarps of Zanthoxylum piperitum |
Author |
Seo Young Yang, Bui Huu Tai, Seok Bean Song, Wei Li, Xi Tao Yan, Ya Nan Sun, Nguyen Phuong Thao,, Young Ho Kim* |
Keywords |
ZP-amide F, Zanthoxylum piperitum, Anti-inflammation, NF-κB, PPAR |
Abstract |
A new aliphatic acid amide, ZP-amide F (1), and eight known compounds, including bungeanumamide A (2), tumuramide C (3), ZP-amide A (4), ZP-amide B (5), ZP-amide D (6), hyperin (7), quercitrin (8), and (−)- sesamin (9), were isolated from pericarps of Zanthoxylum piperitum. The effects of these compounds on TNFα-induced NF-κB activation and transactivational activity of PPARs, including PPARα, PPARβ(δ) and PPARγ subtypes, were evaluated. Compounds 7 and 9 exhibited potent inhibitory effects on TNFα-induced NF-κB activation with IC50 values of 5.50 and 8.10 μM, respectively. Aliphatic acid amide compounds 3, 4 and 6 displayed enhanced effects on PPAR transactivational activity with EC50 values of 47.12, 19.13 and 12.02 μM, respectively. Among them, compound 4 demonstrated an increase in PPARα transactivational activity, compound 3 showed a moderate increase on all PPAR subtypes, whereas compound 6 displayed weak PPAR transactivational activity. |
Page |
2361 - 2366 |
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