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Bulletin of the Korean Chemical Society (BKCS)

ISSN 0253-2964(Print)
ISSN 1229-5949(Online)
Volume 35, Number 7
BKCSDE 35(7)
July 20, 2014 
 
Title
 Synthesis of New 4-(tert-Octyl)phenol Derivatives and Their Anticancer Activity against Human Prostate and Lung Cancer Cell Lines
Author
 Haiyan Che, Yuanying Fang, Santosh K. Gurung, Jun Luo, Deok Hyo Yoon, Gi-Ho Sung, Tae Woong Kim, Haeil Park*
Keywords
 Cordyceps militaris, Militarin, 4-(tert-Octyl)phenol derivatives, D-Mannitol substructure, Anticancer activity
Abstract
 4-(tert-Octyl)phenol derivatives bearing the D-mannitol substructure (6a, 6b, 7) were prepared from Dmannitol and evaluated their anticancer activity against human lung (A549) and prostate (Lncap, Du145, PC3) cancer cell lines. Among derivatives tested, the bis(tert-octyl)phenoxy compound 7 exhibited strongest proliferation inhibitory activities against human cancer cell lines tested, especially high sensitivity to human Du145 prostate cancer cells (IC50 = 7.3 μM).
Page
 2038 - 2042
Full Text
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