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Bulletin of the Korean Chemical Society (BKCS)

ISSN 0253-2964(Print)
ISSN 1229-5949(Online)
Volume 35, Number 4
BKCSDE 35(4)
April 20, 2014 

Synthesis of Imidazo[1,2-a]pyridines and Pyrido[1,2-a]pyrimidines in Water and their SNAr Cyclizations
Langpoklakpam Gellina Chanu, Thokchom Prasanta Singh, Yong Ju Jang, Yong-Jin Yoon, Okram Mukherjee Singh*, Sang-Gyeong Lee*
Tetrahydroimidazo[1,2-a]pyridines, Tetrahy-dropyrido[1,2-a]pyrimidines, Imidazo and pyrido fused [1,8] naphthyridine tetracyclic, One-pot and multicomponent
Synthesis of tetrahydroimidazo[1,2-a]pyridines and tetrahydropyrido[1,2-a] pyrimidines by a one-pot and three component reaction of α-oxoketenedithioacetals, diamines and DMAD in water has been described. Different routes for accessing the desired compounds were examined and a few specially designed-substrates have been utilized further to afford the new imidazo and pyrido fused [1,8] naphthyridine tetracyclic compound by SNAr intramolecular cyclization.
994 - 1000
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