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Bulletin of the Korean Chemical Society (BKCS)

ISSN 0253-2964(Print)
ISSN 1229-5949(Online)
Volume 33, Number 8
BKCSDE 33(8)
August 20, 2012 

Direct Palladium-Catalyzed C-4 Arylation of Tri-substituted Furans with Aryl Chlorides: An Efficient Access to Heteroaromatics
Hai Yang*, Zhishuo Zheng, Jian Zeng, Huajie Liu, Bing Yi*
Palladium catalyst, Coupling reaction, Furan, Arylation, Aryl chloride
A series of functionalized furans were synthesized by way of a palladium -catalyzed coupling reaction of 2,3,5- trisubstituted furans with aryl chlorides through C-H bond cleavages at C-4 position. The feature of the reaction was facilitative preparation of furan derivatives with good functional group tolerance. All reactions gave the desired products in moderate to good yields in the presences of BuAd2P and t-BuOK in DMF at 120 oC after 15 h.
2623 - 2626
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