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Bulletin of the Korean Chemical Society (BKCS)

ISSN 0253-2964(Print)
ISSN 1229-5949(Online)
Volume 33, Number 7
BKCSDE 33(7)
July 20, 2012 

High Yielding [18F]Fluorination Method by Fine Control of the Base
Sang Ju Lee, Seung Jun Oh*, Dae Yoon Chi, Dae Hyuk Moon, Jin Sook Ryu
[18F]Fluoride, [18F]Fluorination, KOMs, [18F]FLT, Nucleophilic substitution
New [18F]F-fluorination methods using a minimized amount of precursor has been developed by controlling the base concentration. In the first method, pre-conditioning of the anion exchange cartridge with K2CO3 solution or water was carried out. The trapped [18F]fluoride on the cartridge was then eluted by KOMs or KOTf solution. [18F]F-Fluorination could be performed without additional base. In the second method, the QMA cartridge was preconditioned with KOMs solutions. Trapped [18F]fluoride on the QMA was then eluted with KOMs and additional base, such as KOH, K2CO3, and KHCO3, was added into the reaction vessel. Method 1 showed a [18F]F-incorporation yield of 20.9% for [18F]FLT synthesis with 5 mg of precursor. Unlike method 1, a [18F]F-incorporation yield of 91.4% was achieved from the same amount of precursor in method 2.
2177 - 2180
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