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Bulletin of the Korean Chemical Society (BKCS)

ISSN 0253-2964(Print)
ISSN 1229-5949(Online)
Volume 31, Number 12
BKCSDE 31(12)
December 20, 2010 

Amphiphilic cyclotriphosphazenes grafted with branched oligopeptides
Vithal B Jadhav, Udaya S Toti, Jin Xin Cui, Yong Joo Jun, Youn Soo Sohn*
Branched oligopeptide, Cyclotriphosphazenes, Micelles
Branched oligopeptides prepared by coupling a very hydrophobic aspartic diamino acid ethyl ester such as Asp (LeuEt)2, Asp(IleEt)2 and Asp(PheEt)2 to glycine or glycylphenylalanine were grafted to the cyclotriphosphazene backbone bearing an equimolar hydrophilic poly(ethylene glycol) (PEG). The properties of the resultant amphiphiles were examined in comparison with those of the linear oligopeptide analogues previously reported. All cyclic phosphazene trimers grafted with the branched tetra- and pentapeptides displayed a normal trend of thermosensitivity depending on their hydrophilic to hydrophobic balance, but the stability and particle size of their micelles were found to be greatly dependent on the fine structure of the branched oligopeptides grafted. The trimers bearing branched tetrapeptides with a low hydrophobicity were found to form unstable micelles initially, which reassemble into thermodynamically more stable polymersomes.
3735 - 3739
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