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Bulletin of the Korean Chemical Society (BKCS)

ISSN 0253-2964(Print)
ISSN 1229-5949(Online)
Volume 31, Number 6
BKCSDE 31(6)
June 20, 2010 

 
Title
An Efficient Synthesis of 3,4-Dihydro-3-substituted-2H-naphtho[2,1-e][1,3]oxazine
Derivatives Catalyzed by Zirconyl(IV) Chloride and Evaluation
of its Biological Activities
Author
Amol H Kategaonkar, Swapnil S Sonar, Rajkumar U Pokalwar, Atul H Kategaonkar, Bapurao B Shingate, Murlidhar S Shingare*
Keywords
1,3-Oxazines, Zirconyl(IV) chloride, Grinding, Antibacterial, Antifungal
Abstract
An efficient and novel one-pot synthesis of new 3,4-dihydro-3-substituted-2H-naphtho[2,1-e][1,3]oxazine derivatives from 1-naphthol, various anilines and formalin at room temperature grinding is presented. The six-membered N,O-heterocyclic skeleton was constructed via zirconyl(IV) chloride promoted Mannich type reaction. In vitro antimicrobial activities of synthesized compounds have been investigated against Gram-positive Bacillus subtilis, Gram negative Escherichia coli and two fungi Candida albicans and Aspergillus niger in comparison with standard drugs. The results of preliminary bioassay indicate that some of title compounds possess significant antibacterial and antifungal activity.
Page
1657 - 1660
Full Text
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