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Bulletin of the Korean Chemical Society (BKCS)

ISSN 0253-2964(Print)
ISSN 1229-5949(Online)
Volume 31, Number 5
BKCSDE 31(5)
May 20, 2010

Title	Synthesis of Benzoxazole Amides as Novel Antifungal Agents against Malassezia Furfur
Author	Beom Joon Kim, Jinah Kim, Young Kook Kim, Soon Yong Choi, Hea Young Park Choo*
Keywords	Benzoxazole amides, Antifungal, Malassezia furfur
Abstract	Malassezia is a pathogenic fungus that causes skin diseases, such as tinea versicolor, atopic dermatitis and fatal sepsis. We report the synthesis of a series of benzoxazole amides and evaluation of their antifungal activity against Malassezia furfur. Twelve benzoxazole amides were prepared through the cyclization of the substituted 2-hydroxy aniline with N-(bis-methylsulfanylmethylene) amides. Among the prepared compounds, the compounds 4a, 8b, 8c and 8d showed in vitro antifungal activity.
Page	1270 - 1274
Full Text	PDF

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