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Bulletin of the Korean Chemical Society (BKCS)

ISSN 0253-2964(Print)
ISSN 1229-5949(Online)
Volume 31, Number 4
BKCSDE 31(4)
April 20, 2010

Title	Facile Preparation of 2-Arylbenzo[b]furan Molecules and Their Anti-inflammatory Effects
Author	Jung Woon Hwang, Da Hye Choi, Jae Ho Jeon, Jin Kyung Kim, Jong Gab Jun*
Keywords	Ailanthoidol, XH-14, 2-Arylbenzo[b]furan, Anti-inflammatory, Nitric oxide
Abstract	An efficient and practical preparation of 2-arylbenzo[b]furan molecules including natural egonol, XH-14, ailanthoidol, and unnatural derivatives is demonstrated using Sonogashira coupling, iodine induced cyclization and Wittig reaction. Anti-inflammatory effects of the prepared benzo[b]furans were examined in lipopolysaccharide (LPS)-stimulated RAW 264-7 macrophages. The results showed that ailanthoidol, XH-14 and three other unnatural derivatives (9-10, 13) inhibited significantly the production of inflammatory mediator nitric oxide without showing cytotoxicity.
Page	965 - 970
Full Text	PDF

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