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Bulletin of the Korean Chemical Society (BKCS)

ISSN 0253-2964(Print)
ISSN 1229-5949(Online)
Volume 30, Number 12
BKCSDE 30(12)
December 20, 2009

Title	Total Synthesis of Licochalcone E
Author	Goo Yoon, Zhiguo Liu, Hee Jin Jeong, Seung Hoon Cheon*
Keywords	Licochalcone E, Aldol condensation, Claisen rearrangement, Synthesis
Abstract	Total synthesis of (±)-licochalcone E (1), an allyl retrochalcone isolated from roots of Glycyrrhiza inflata, has been achieved from 4-tetrahydropyranyloxyacetophenone (7) with (E)-2-methoxy-4-(2-methyl-2-butenyloxy)benzaldehyde (6) or (Z)-2-methoxy-4-(2-methyl-2-butenyloxy)-benzaldehyde (11) through a convergent strategy involving aldol condensation and Claisen rearrangement as key steps.
Page	2959 - 2961
Full Text	PDF

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