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Bulletin of the Korean Chemical Society (BKCS)

ISSN 0253-2964(Print)
ISSN 1229-5949(Online)
Volume 30, Number 10
BKCSDE 30(10)
October 20, 2009 

Bioactive Cyclopentenone Derivatives from Marine Isolates of Fungi
Zhile Feng, Alain S Leutou, Guohua Yang, Viviane N Nenkep, Xavier N Siwe, Hong Dae Choi, Jung Sook Kang, Byeng Wha Son*
Trichoderma viride, Rhizopus stolonifer, Cyclopentenone, Myrothenone, Botrytinone
As part of an effort to discover bioactive natural products from marine sources, we investigated the bioactive secondary metabolites from two marine isolates of the fungi, Trichoderma viride and Rhizopus stolonifer. Three cyclopentenones, myrothenones A (1) and B (2) and trichodenone A (3), were isolated from T. viride and two cyclopentenones, 2-bromomyrothenone B (4) and botrytinone (5), were isolated from R. stolonifer. The molecular structures and absolute stereochemistries of the cyclopentenones were determined from chemical and physicochemical evidence, including quantum chemistry calculations, X-ray analysis, and the circular dichroism (CD) exciton chirality method. Myrothenone A (1) displays tyrosinase inhibitory activity, with an IC50 value of 6.6 μM, and is therefore more active than the positive control, kojic acid.
2345 - 2350
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