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Bulletin of the Korean Chemical Society (BKCS)

ISSN 0253-2964(Print)
ISSN 1229-5949(Online)
Volume 30, Number 6
BKCSDE 30(6)
June 20, 2009 

Superparamagnetic Gd- and Mn-substituted Magnetite Fluids Applied as MRI Contrast Agents
Jong Hee Kim, Chang Hyun Lee, Sang Kuk Lee*
Superparamagnetism, Magnetic nanoparticle, Imaging agent, In vitro, In vivo
The experimental particle samples included (Mn0.1Fe0.9)OㆍFe2O3 and FeOㆍ(Gd0.1Fe0.9)2O3 with Mn2+ and Gd3+ substitutions in inverse spinel Fe3O4. A lecithin surfactant was adsorbed onto the magnetic particles by ultrasonication. The samples prepared showed excellent dispersibility at the mean size of 13 nm; their saturation magnetization values were 63 emu/g for the bare and Mn-substituted magnetites, and 56 emu/g for the Gd-substituted magnetite. The crystal structure of the substituted magnetites was very similar to that of the bare magnetite, due to a small amount of 0.1 mole fraction substituted in synthesizing the magnetite. The magnetite fluids, according to T2-weighted MR images, effectively diminished the signal intensity in the liver and spleen of Sprague-Dawley rats.
1305 - 1308
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