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Bulletin of the Korean Chemical Society (BKCS)

ISSN 0253-2964(Print)
ISSN 1229-5949(Online)
Volume 30, Number 4
BKCSDE 30(4)
April 20, 2009 

Determination of Correlation Times of New Paramagnetic Gadolinium MR Contrast Agents by EPR and 17O NMR
Hee Kyung Kim, Gang Ho Lee, Tae Jeong Kim*, Yongmin Chang*
MRI CA, Gadolinium chelate, Tranexamate, Correlation times
The work describes EPR and 17O NMR measurements followed by theoretical calculation of the rotational correlation time (τR), the water residence time (τm), and the longitudinal electronic spin relaxation time (T1e) for two new gadolinium complexes 1 and 2 of the type [Gd(L)(H2O)] (L = tranexamic esters) in order to investigate their efficiency as a paramagnetic contrast agent (PCA). Of three correlation times, τR plays a major and predominant role to the unusually high relaxivity of 1 and 2 as compared with that of clinically approved MR CAs such as [Gd(DTPA)(H2O)]2- (Magnevist?), [Gd(DTPA?BMA)(H2O)] (Omniscan?), and [Gd(DOTA)(H2O)]- (Dotarem?). The presence of bulky tranexamic ester in the ligand seems to be responsible for the conformational rigidity, which in turn causes such great an increase in τR.
849 - 852
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