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Bulletin of the Korean Chemical Society (BKCS)

ISSN 0253-2964(Print)
ISSN 1229-5949(Online)
Volume 30, Number 1
BKCSDE 30(1)
January 20, 2009 

Synthesis and Biological Evaluation of Decursin, Prantschimgin and Their Derivatives
Yan Xia, Kyung Hoon Min*, Kyeong Lee*
Coumarins, Decursin, Prantschimgin, Multidrug resistance, P-glycoprotein
The synthesis of coumarin-based natural products and their derivatives is described. In vitro MDR reversal activities of the synthesized compounds were evaluated in P-glycoprotein over-expressing human sarcoma cell line MES-SA/DX5. Some of the coumarin derivatives were found to show potent MDR reversal activity. In particular, pyridyl derivative (15e) exhibited more potency than verapamil.
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