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Bulletin of the Korean Chemical Society (BKCS)

ISSN 0253-2964(Print)
ISSN 1229-5949(Online)
Volume 29, Number 12
BKCSDE 29(12)
December 20, 2008

Title	Design and Synthesis of 5''-Iodoneplanocin A and Its Analogues as Potential S-Adenosylhomocysteine Hydrolase Inhibitor†
Author	Ah Young Park, Kyung Ran Kim, Hyung Rock Lee, Jin Ah Kang, Won Hee Kim, Pusoon Chun, Pervez Ahmad, Lak Shin Jeong, Hyung Ryong Moon*
Keywords	5''-Iodoneplanocin A, S-Adenosylhomocysteine hydrolase, Steric hindrance, Michael additioniodination-elimination, Michael addition-elimination reaction
Abstract	5''-Iodoneplanocin A (1) and its analogues 2 and 3 were designed and synthesized as potential SAHH inhibitor via iodocyclopentenol 6, which was prepared using a Michael addition-iodination-elimination process. All final compounds did not show antiviral activity, maybe due to a steric hindrance induced by 5''-iodo substituent.
Page	2487 - 2490
Full Text	PDF

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