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Bulletin of the Korean Chemical Society (BKCS)

ISSN 0253-2964(Print)
ISSN 1229-5949(Online)
Volume 29, Number 12
BKCSDE 29(12)
December 20, 2008 

Design and Synthesis of 5''-Iodoneplanocin A and Its Analogues as Potential S-Adenosylhomocysteine Hydrolase Inhibitor†
Ah Young Park, Kyung Ran Kim, Hyung Rock Lee, Jin Ah Kang, Won Hee Kim, Pusoon Chun, Pervez Ahmad, Lak Shin Jeong, Hyung Ryong Moon*
5''-Iodoneplanocin A, S-Adenosylhomocysteine hydrolase, Steric hindrance, Michael additioniodination-elimination, Michael addition-elimination reaction
5''-Iodoneplanocin A (1) and its analogues 2 and 3 were designed and synthesized as potential SAHH inhibitor via iodocyclopentenol 6, which was prepared using a Michael addition-iodination-elimination process. All final compounds did not show antiviral activity, maybe due to a steric hindrance induced by 5''-iodo substituent.
2487 - 2490
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