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Bulletin of the Korean Chemical Society (BKCS)

ISSN 0253-2964(Print)
ISSN 1229-5949(Online)
Volume 29, Number 6
BKCSDE 29(6)
June 20, 2008

Title	A Comparison of Analytical Methods for the Content and Purity of Cefradine
Author	Myung Ho Hyun, Euh Duck Jeong, Min Seob Shin, Jong Sung Jin*
Keywords	Cefradine, Cefalexin, Cefadroxil, Impurity
Abstract	Two HPLC methods such as cefadroxil and cefalexin methods were compared in their performance for the quantitative analysis of the content and purity of β -lactamic antibiotic, cefradine, for six bulk drug samples. Between the two methods, the cefadroxil method prescribed by the European Pharmacopoeia (EP) for the determination of impurities in cefradoxil was superior to the cefalexin method prescribed by the EP and by the United States Pharmacopeia (USP) for the determination of cefalexin impurity in cefradine in terms of the greater stability of the chromatogram baselines and the higher precision, i.e., the lower % relative standard deviation (RSD). Based on the comparison of the two HPLC methods, the cefadroxil method was recommended to replace the TLC method, which has been prescribed by the EP as the official method for determination of extraneous impurities in cefradine.
Page	1185 - 1189
Full Text	PDF

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