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Bulletin of the Korean Chemical Society (BKCS)

ISSN 0253-2964(Print)
ISSN 1229-5949(Online)
Volume 28, Number 11
BKCSDE 28(11)
November 20, 2007

Title	Detection of Avidin Based on Rugate-structured Porous Silicon Interferometer
Author	Youngdae Koh, Sung Jin Kim, Jaehyun Park, Cheolyoung Park, Sungdong Cho, Hee-Gweon Woo, Young Chun Ko, Honglae Sohn
Keywords	Rugate structure, Porous silicon, Biotin, Avidin
Abstract	Biosensor based on rugate PSi interferometer for the detection of avidin has been described. Rugate PSi fabricated by applying a computer-generated pseudo-sinusoidal current waveform has been prepared for the application as a label-free biosensor based on porous silicon interferometer. The fabrication, optical characterization, and surface derivatization of a rugate PSi has been described. The method to fabricate biotinderivatized rugate PSi has been investigated. The surface and cross sectional morphology of rugate PSi are obtained with SEM. FT-IR spectroscopy is used to characterize the oxidation and functionalization reaction of rugate PSi sample. Binding of the avidin into the biotin-derivatized rugate PSi induces a change in refractive index. A red-shift of reflectivity by 18 nm in the reflectivity spectrum is observed, when the biotin-modified rugate PSi was exposed to a flow of avidin.
Page	2083 - 2088
Full Text	PDF

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