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Bulletin of the Korean Chemical Society (BKCS)

ISSN 0253-2964(Print)
ISSN 1229-5949(Online)
Volume 28, Number 8
BKCSDE 28(8)
August 20, 2007 

Isolation and Characterization of a New Alkaloid from the Seed of Prunus persica L. and Its Anti-inflammatory Activity
Jung-Rae Rho, Chang-Soo Jun, Young-Ae Ha, Myung-Ja Yoo, Ming-Xun Cui, Hwa-Seung Baek, Jin-A Lim, Young-Haeng Lee, Kyu-Yun Chai*
Persicaside, Nitric oxide, Prostaglandin E2, Inducible nitric oxide synthase, Cyclooxygenase-2
Persicaside has been isolated as a new alkaloid natural compound from a methanol (EtOA)-soluble extract of Prunus persica seed. It was purified by a combination of chromatographic techniques and recrystallization. The structure of Persicaside was determined by extensive NMR experiments and mass ppectroscopic data. It inhibited nitric oxide (NO) and prostaglandin E2 (PGE2) production via suppression of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2 expression in rat osteoblast sarcoma cells (ROS 17/2.8) in concentration-dependent manner whereas it spares the COX-1 enzyme activity.
1289 - 1293
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