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Bulletin of the Korean Chemical Society (BKCS)

ISSN 0253-2964(Print)
ISSN 1229-5949(Online)
Volume 28, Number 8
BKCSDE 28(8)
August 20, 2007

Title	Isolation and Characterization of a New Alkaloid from the Seed of Prunus persica L. and Its Anti-inflammatory Activity
Author	Jung-Rae Rho, Chang-Soo Jun, Young-Ae Ha, Myung-Ja Yoo, Ming-Xun Cui, Hwa-Seung Baek, Jin-A Lim, Young-Haeng Lee, Kyu-Yun Chai*
Keywords	Persicaside, Nitric oxide, Prostaglandin E2, Inducible nitric oxide synthase, Cyclooxygenase-2
Abstract	Persicaside has been isolated as a new alkaloid natural compound from a methanol (EtOA)-soluble extract of Prunus persica seed. It was purified by a combination of chromatographic techniques and recrystallization. The structure of Persicaside was determined by extensive NMR experiments and mass ppectroscopic data. It inhibited nitric oxide (NO) and prostaglandin E₂ (PGE₂) production via suppression of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2 expression in rat osteoblast sarcoma cells (ROS 17/2.8) in concentration-dependent manner whereas it spares the COX-1 enzyme activity.
Page	1289 - 1293
Full Text	PDF

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